FcγRIIa
نویسندگان
چکیده
منابع مشابه
Platelet FcγRIIA signaling: new clues for HIT.
In this issue of Blood, Zhou et al provide novel insights into Fc gamma type 2 receptor A (FcgRIIA)–mediated platelet activation. By identifying a negative regulator of FcgRIIA signaling, which is influenced by microRNA miR-148a, they present the first evidence of modulation of platelet function by microRNAs in vivo. They show that inhibition of miR-148a prevents thrombosis after immune complex...
متن کاملHuman FcγRIIA induces anaphylactic and allergic reactions.
IgE and IgE receptors (FcεRI) are well-known inducers of allergy. We recently found in mice that active systemic anaphylaxis depends on IgG and IgG receptors (FcγRIIIA and FcγRIV) expressed by neutrophils, rather than on IgE and FcεRI expressed by mast cells and basophils. In humans, neutrophils, mast cells, basophils, and eosinophils do not express FcγRIIIA or FcγRIV, but FcγRIIA. We therefore...
متن کاملFcγRIIa defunctioning polymorphism in paediatric patients with renal allograft
Introduction Fc gamma receptor (FcγR) IIa is considered the most widely distributed of the three classes of Fc receptors, and it expresses an allelic polymorphism. This type of polymorphism may modify the immune response and may be an important factor for some diseases. The aim of the study reported herein was to evaluate the association between the FcγRIIa polymorphism and susceptibility to bo...
متن کاملPlatelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet activity often results in thrombotic complications leading to myocardial infarction and stroke. Activation of the FcγRIIa receptor leads to immune-mediated thrombosis, which is often life threatening in patients undergoing heparin-induced thrombocytopenia or sepsis. Inhib...
متن کاملShifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.
Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developing RA. Within the hFcγRIIA intracytoplasmic domain, there are 2 conserved tyrosine residues arranged ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2018
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2018.04.046